Thats why they didnt even fund the fluvoxamine trial, he told me. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here. Some countries dont have fluvoxamine so this is the alternative. Doctors who have used fluvoxamine in the US and other countries swear by it. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. And, according to three members of CETFs scientific advisory board, he put pressure on them to promote fluvoxamine for clinical use without conclusive data that it worked for covid. Di scl ai mer: T he vi ews expressed i n t hi s art i cl e are my own personal opi ni on based on my 1, 000+ hour st udy of cut t i ng edge . The effect size is huge if the drug is given early right after symptoms start. Drug researchers at Washington University in St. Louis reached out to Kirsch looking for $67,000 to finish a very smallbut placebo-controlledtrial. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. This alone will give roughly a 50% effect size and explains why all of the the SSRIs are effective including those that do not activate the Sigma1 receptor (e.g., Paroxetine). The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. Peter Meinke, another former board member, spent nearly three decades in drug discovery at Merck. As noted before, the repository has a link to the 1 hour serotonin lecture. He wrote on his personal website that hed been advised that being associated with the drug would immediately trash my credibility.. Its all about NIH saying it is OK. . You see this with people who have a lot of money, who think that reflects their intelligence, Richman told me. If you start 5 days after symptoms, all bets are off. Kirsch and his wife, Michele, fund a charitable foundation, which by 2007 had given $75 million to different causes. ICER: People are dying. I couldn't agree more. Fluvoxamine was reportedly added to just 2 practice guidelines (. P-value was 10^-14 on that study (done by Dr. Seftel). Personal life. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. After I ended the Zoom meeting, Satterfield called me to apologize for cutting us off. He started a covid-19 vaccine company. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Steve Kirsch. . Thats pretty typical, but your mileage may vary. He was recently featured on 60 Minutes which highlighted his . The NIH never did a risk benefit analysis of this drug. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. All the researchers are convinced the drug works. But not 150K. We look for advances that will have a big impact on our lives and break down why they matter. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. Dr. Seftel is an NIH-funded researcher and an NIH reviewer. The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). Even though they spent only 45 minutes and just reviewed the 2 clinical studies and some plausible mechanisms of action (and ignored anecdotal evidence and multiple retrospective trials, all of which were supportive), after the meeting they voted overwhelmingly (11 to 5 with 4 being neutral) in favor of having doctors talk to their patients about using fluvoxamine if they have COVID using a "shared decision making" process. He has a history of giving away some of his millions to good causes, and when COVID-19 began. Fluvoxamine is used commonly to treat obsessive-compulsive disorder (OCD), social anxiety disorder and depression. Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. That way you can start immediately. Proxalutamide and fluvoxamine pushers and the early treatment grift. Note that a total of 77 people got the drug, not 65. For decades, coders wrote critical systems in C and C++. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. Some people report mild nausea while on the drug (stops when stop the drug). Note that some of these articles are inaccurate. FDA official fluvoxamine rejection. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Zero. Fluvoxamine, COVID, pandemic, . The drug was FDA-approved more than 65 years ago. Always be self aware when using fluvoxamine. 95% confidence effect size is 75% or more. So there were too few events in the placebo group and they werent recruiting fast enough. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. It used to be that a Phase 3 study would do it. Its board told him that if he wanted to remain part of the company he would have to stop making public anti-vaccine statements. . Consider masks by contrast. Theres nothing there.). If you were drowning and we had no known standard of care to save your life and someone had a life preserver which worked 160 times in a row, should we throw them the life preserver or let them drown because we aren't absolutely sure the life preserver's benefit > risk (since just because it worked 160 times in a row and there is a 99.99% chance the effect didn't happen by chance, we could have just gotten lucky). Seftel used a 50mg BID dosing for 14 days which was one third of the max dose used in the Lenze study. I've asked people, "there's a lot of evidence here it's not just a small phase 2 RCT. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. Compulsive hand washing? While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. So it was both obvious and convincing the difference between the groups to the workers and the track management. Both drugs have compelling data that is hard to explain if the drug doesn't work. Now weve lost the high ground, Morris told me. I took it myself at that dosage and noticed zero side effects. That trial has now been completed, and the researchers are analyzing their data. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. So much for evidence-based medicine. Twenty-four years ago, . , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. There may be a depression of libido while on drug, but since the drug is taken on acute basis, this is only temporary and it reverses once the drug is stopped. It was tested in coronavirus patients because fluvoxamine has very strong anti-inflammatory properties. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. The incident, he added, was completely in keeping with his personality.. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. Some people report mild nausea while on the drug (stops when stop the drug). and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora There is no evidence fluvoxamine is harmful and led to a worse outcome. He's founded 7 companies, 2 with billion dollar valuations. The FDA approved Molnupiravir which was less effective. See this. But the whole process has gone too slowly for Kirsch. If not, they should at least acknowledge that fluvoxamine might be helpful by at least listing it as a possibility. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. David Boulware, a researcher at the University of Minnesota, received $125,000 to test the drug against covid. Medicine isnt about saving lives anymore. $1M reward: Do we need more data re: Fluvoxamine for COVID-19? If you take fluvoxamine, please avoid caffeine while on the drug. So you can address your OCD and if you get COVID, youll can up the dose. This looks ominous, but it harmless. Added to FLCCC protocols and Fareed-Tyson protocol among others. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. In other cases, stop cold turkey. In-patient use. I am not aware of a single case where taking the made things worse, e.g., person was doing fine BEFORE the drug and symptoms worsened after taking the drug. iRobot said it had consent to collect this kind of data from inside homesbut participants say otherwise. This is what the Seftel trial at Golden Gate fields used. But how many did it help? BOMBSHELL: Top biostats professor admits we have NO CLUE # of people KILLED by COVID vaccines, he wrote. After several failed attempts to stop the progression of his disease, he designed his own protocol for chemotherapy and doctor-shopped to find an oncologist who would give it to him. Steve Kirsch, current director of the Covid 19 Early Treatment fund is an MIT alumni who has made a career as a tech entrepreneur. He is frequently brash and interruptive, peppering dire warnings about vaccines with veiled aspersions toward Anthony Fauci and vague references to influential people who agree with him in private but cannot speak publicly. Those days are gone. The sooner you start, the better the outcomes. That study was featured on 60 Minutes. How covid-19 conspiracy videos keep getting millions of views. You can experience serious side effects if you do not pay attention to interactions such as if you are currently on another SSRI of a different type. Here's why. No long haul symptoms if you start the drug ASAP after first symptoms. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. The babys brain was split in half, and it was just covered with blood. Instead, it erodes confidence in our government to provide timely advice that is in the public interest. There are other non-prescription things you should always have on hand. It is very safe: There is no evidence fluvoxamine is harmful and led to a worse outcome. In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. Now they turn to Rust. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. But an Editor's Note urged physicians to treat this as a hypothesis and not as a basis for clinical decision-making. YouTube , , , fluvoxamine, , , , , , , , , , Repurposed drugs are safer and more effective than the current vaccines. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. . The web value rate of skirsch.io is 2 . Dosing. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. A very short op-ed arguing for using fluvoxamine against COVID. Be warned!. Talking to Kirsch is an exhausting experience. In California, Silicon Valley tech entrepreneur Steve Kirsch was also thinking about the pandemic. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. This give another 50% of benefit. It could do nothing. This drug can save your life but you have to ask for it! Ivermectin has been falsely promoted as a covid treatmentbut for those who use the drug legitimately, seeing it become a piece of anti-vaccine misinformation is disconcerting. It used to be that a Phase 3 study would do it. With little government funding available for such work, Kirsch founded the Covid-19 Early Treatment Fund (CETF), putting in $1 million of his own money and bringing in donations from Silicon Valley luminaries: the CETF website lists the foundations of Marc Benioff and Elon Musk as donors. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. Ive talked to doctors who are extremely familiar with the drug and all the trial results and they would prescribe it to their patients. The Lancet paper showed that if you were treated early enough and took the drug as prescribed (it only works if you take it), it was shown to reduce your chance of death by 12X making it far more effective than any other drug for COVID. The combined p value of the two studies is <.0001. He pushes fluvoxamine, an anti-depression drug which despite doing very well in covid treatment studies has been strangely neglected. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. Over the summer, the conflict reached his most recent startup, M10. Hes also made several videos and podcasts with Vladimir Zelenko, the conspiracy theorist doctor who convinced Trump to take hydroxychloroquine. An MIT Technology Review investigation recently revealed how images of a minor and a tester on the toilet ended up on social media. All have had a 100% success record in keeping their patients out of the hospital. [NIH] doesnt want any of these treatments. It cant be more clear than this. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. There are now 5 independent observational studies that show that the drug works (2 in France, 1 in Germany, 2 in the US). Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. It was 25 years ago yesterday that Andrew Wakefield launched the modern iteration of the antivaccine movement.In doing so, he laid down a template that antivax quacks today still follow. . Thats what creates some of these heroes.. Jeffrey Glenn, an infectious disease professor at Stanford University, calls the inaction on the current evidence on the table "criminal.". The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. No long haul symptoms if you start the drug ASAP after first symptoms. He retired at the largest pension in federal history. He prefers iconoclastic approaches, whether by directly funding asteroid detection or advocating for nuclear power to combat global warming. They knew in advance it was coming and on the day the paper was published they ignored it entirely. Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. He's discovered a common medication that's highly effective in minimizing the impacts of COVID-19 - two studies have proven so. Its the gold standard of medical evidence. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. Steve Kirsch is looking for an explanation for 171,000 excess deaths. Physicians who use the drug for COVID now swear by it. Fluvoxamine (Luvox) is a Selective Serotonin Receptor Inhibitor (SSRI) that is clinically indicated for OCD in children, and can be used off label for depression. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. I fully expected both organizations to do absolutely nothing. The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. It was tested in. . Adverse reactions/side effects. Thats pretty typical, but your mileage may vary. and increased heart rate (which could be nerves about the dilated pupils). He has a BS/MS in Electrical Engineering and Computer Science from MIT. The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. Dosage there is 30mg once a day. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). more time. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. The post read: "I will be featured on 60 Minutes this Sunday talking about fluvoxamine as an effective treatment for COVID-19 to prevent hospitalization and death. To protect M10 from my COVID-19 vaccination opinions, I will no longer post about my vaccination concerns here.. I learned this the hard way. My experience is very typical. Our in-depth reporting reveals whats going on now to prepare you for whats coming next. In other cases, stop cold turkey. Paper reviewing the evidence and mechanisms of action for fluvoxamine: Lenze Phase 2 RCT published Nov 12, 2020: Seftel RWE trial that confirmed the Phase 2 trial published Feb 1, 2021. Its whether Merck can make a killing that matters. He may not be a good scientist, but hes smart, says WVUs Feinberg. My favorite dosage is 50mg twice a day for 14 days. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. I think we did rigorous reviews of proposals for research.. . The WashU Phase 3 study hasnt been disclosed yet, but they had compliance problems with their patients this time around (phase 2 was local so the patients got the drug early and also were very compliant and the placebo group was truly taking nothing). He has made millions from these projects, even if they have not turned him into a household name. Timing is everything with respect to outcomes. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. 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